View source for 6kyx


==Crystal Structure of Staphylococcus aureus response regulator ArlR DNA binding domain with His tag cleaved==
<StructureSection load='6kyx' size='340' side='right'caption='[[6kyx]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[6kyx]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Staphylococcus_aureus Staphylococcus aureus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6KYX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6KYX FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.0048&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6kyx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6kyx OCA], [https://pdbe.org/6kyx PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6kyx RCSB], [https://www.ebi.ac.uk/pdbsum/6kyx PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6kyx ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/ARLR_STAA8 ARLR_STAA8] Member of the two-component regulatory system ArlS/ArlR involved in the regulation of adhesion, autolysis, multidrug resistance and virulence. ArlS/ArlR affects expression of the multidrug resistance transporter NorA and interacts with both Agr (virulence accessory gene regulator) (negatively) and SarA (staphylococcal accessory regulator) (positively) to modulate several virulence factor genes, including ssp (serine protease), spa (surface protein A) and hla (alpha-hemolysin). Could inhibit biofilm development by a mechanism independent of the presence of the poly-N-acetylglucosamine (PNAG). Also, Arl proteins are required for the efficient activity of DNA gyrase inhibitors and high osmolarity on spa expression.<ref>PMID:10633099</ref> <ref>PMID:10869073</ref> <ref>PMID:11454217</ref> <ref>PMID:15528666</ref> <ref>PMID:16030226</ref> 

==See Also==
*[[Response regulator 3D structure|Response regulator 3D structure]]
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Staphylococcus aureus]]
[[Category: Ouyang Z]]
[[Category: Wen Y]]