View source for 6ivy


==Crystal structure of iron-bound HitA from Pseudomonas aeruginosa==
<StructureSection load='6ivy' size='340' side='right'caption='[[6ivy]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[6ivy]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Pseudomonas_aeruginosa_PAO1 Pseudomonas aeruginosa PAO1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6IVY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6IVY FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.9999994&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FE:FE+(III)+ION'>FE</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6ivy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6ivy OCA], [https://pdbe.org/6ivy PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6ivy RCSB], [https://www.ebi.ac.uk/pdbsum/6ivy PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6ivy ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/Q9HVA8_PSEAE Q9HVA8_PSEAE] 
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
Gallium nitrate (Ganite) is a potential drug for the treatment of Pseudomonas aeruginosa infection. CRISPR/Cas9-based gene mutagenesis studies reveal that siderophore pyochelin-facilitated uptake and an ABC transporter are two major Ga(3+) internalization pathways in Pseudomonas aeruginosa (P. aeruginosa). Crystal structures reveal that Ga(3+) and Fe(3+) occupy exactly the same metal site of HitA, a periplasmic iron-binding protein of the ABC transporter system. The study provides a molecular basis for Ga(3+) internalization by P. aeruginosa and facilitates gallium-based antimicrobial drug development.

Identification and Characterization of a Metalloprotein Involved in Gallium Internalization in Pseudomonas aeruginosa.,Guo Y, Li W, Li H, Xia W ACS Infect Dis. 2019 Oct 11;5(10):1693-1697. doi: 10.1021/acsinfecdis.9b00271., Epub 2019 Sep 5. PMID:31475514<ref>PMID:31475514</ref>

From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
<div class="pdbe-citations 6ivy" style="background-color:#fffaf0;"></div>

==See Also==
*[[Ferric-binding protein|Ferric-binding protein]]
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Pseudomonas aeruginosa PAO1]]
[[Category: Li HY]]
[[Category: Zhang ZR]]