View source for 6ije


==Crystal structure of the type VI amidase immunity (Tai4) from Agrobacterium tumefaciens==
<StructureSection load='6ije' size='340' side='right'caption='[[6ije]], [[Resolution|resolution]] 1.55&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[6ije]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Agrobacterium_tumefaciens Agrobacterium tumefaciens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6IJE OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6IJE FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.55&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6ije FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6ije OCA], [https://pdbe.org/6ije PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6ije RCSB], [https://www.ebi.ac.uk/pdbsum/6ije PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6ije ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/A0A083ZID3_RHIRD A0A083ZID3_RHIRD] 
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
The type VI secretion system (T6SS) comprises needle-shaped multisubunit complexes that play a role in the microbial defense systems of Gram-negative bacteria. Some Gram-negative bacteria harboring a T6SS deliver toxic effector proteins into the cytoplasm or periplasm of competing bacteria in order to lyse and kill them. To avoid self-cell disruption, these bacteria have cognate immunity proteins that inhibit their toxic effector proteins. T6SS amidase effector protein 4 (Tae4) and T6SS amidase immunity protein 4 (Tai4) are a representative of the toxic effector-immunity pairs of the T6SS. Here, the three-dimensional structures of Tai4 and the Tae4-Tai4 complex from Agrobacterium tumefaciens are reported at 1.55 and 1.9 A resolution, respectively. A structural comparison with other Tae4-Tai4 homologs revealed similarities and differences in the catalytic and inhibitory mechanisms among the Tae4 and Tai4 family proteins.

Crystal structure of the Agrobacterium tumefaciens type VI effector-immunity complex.,Fukuhara S, Nakane T, Yamashita K, Ishii R, Ishitani R, Nureki O Acta Crystallogr F Struct Biol Commun. 2018 Dec 1;74(Pt 12):810-816. doi:, 10.1107/S2053230X18016369. Epub 2018 Nov 30. PMID:30511676<ref>PMID:30511676</ref>

From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
<div class="pdbe-citations 6ije" style="background-color:#fffaf0;"></div>
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Agrobacterium tumefaciens]]
[[Category: Large Structures]]
[[Category: Fukuhara S]]
[[Category: Ishii R]]
[[Category: Ishitani R]]
[[Category: Nakane T]]
[[Category: Nureki O]]
[[Category: Yamashita K]]