View source for 6igv


==Kif5b stalk I coiled-coil==
<StructureSection load='6igv' size='340' side='right'caption='[[6igv]], [[Resolution|resolution]] 3.00&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[6igv]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6IGV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6IGV FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.999&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6igv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6igv OCA], [https://pdbe.org/6igv PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6igv RCSB], [https://www.ebi.ac.uk/pdbsum/6igv PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6igv ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/KINH_MOUSE KINH_MOUSE] Microtubule-dependent motor required for normal distribution of mitochondria and lysosomes. May be involved in the mechanisms of growth arrest induced by exposure to DNA-damaging drugs or by cellular senescence (PubMed:9657148). Can induce formation of neurite-like membrane protrusions in non-neuronal cells in a ZFYVE27-dependent manner (PubMed:21976701). Regulates centrosome and nuclear positioning during mitotic entry. During the G2 phase of the cell cycle in a BICD2-dependent manner, antagonizes dynein function and drives the separation of nuclei and centrosomes. Required for anterograde axonal transportation of MAPK8IP3/JIP3 which is essential for MAPK8IP3/JIP3 function in axon elongation (By similarity).[UniProtKB:P33176][UniProtKB:Q2PQA9]<ref>PMID:21976701</ref> <ref>PMID:9657148</ref> 

==See Also==
*[[Kinesin 3D Structures|Kinesin 3D Structures]]
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Mus musculus]]
[[Category: Kong B]]
[[Category: Sun Wp]]
[[Category: Zhang SJ]]