View source for 6gy4


==Crystal structure of the N-terminal KH domain of human BICC1==
<StructureSection load='6gy4' size='340' side='right' caption='[[6gy4]], [[Resolution|resolution]] 1.99&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[6gy4]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6GY4 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6GY4 FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=XPE:3,6,9,12,15,18,21,24,27-NONAOXANONACOSANE-1,29-DIOL'>XPE</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6gy4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6gy4 OCA], [http://pdbe.org/6gy4 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6gy4 RCSB], [http://www.ebi.ac.uk/pdbsum/6gy4 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6gy4 ProSAT]</span></td></tr>
</table>
== Disease ==
[[http://www.uniprot.org/uniprot/BICC1_HUMAN BICC1_HUMAN]] Autosomal dominant polycystic kidney disease. Disease susceptibility is associated with variations affecting the gene represented in this entry. 
== Function ==
[[http://www.uniprot.org/uniprot/BICC1_HUMAN BICC1_HUMAN]] Putative RNA-binding protein. Acts as a negative regulator of Wnt signaling. May be involved in regulating gene expression during embryonic development.<ref>PMID:21922595</ref>  
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Arrowsmith, C H]]
[[Category: Bountra, C]]
[[Category: Burgess-Brown, N]]
[[Category: Delft, F von]]
[[Category: Edwards, A]]
[[Category: Gileadi, O]]
[[Category: Katis, V L]]
[[Category: Newman, J A]]
[[Category: Shrestha, L]]
[[Category: Bicaudal]]
[[Category: Kh domain]]
[[Category: Rna binding]]
[[Category: Rna binding protein]]
[[Category: Transcription]]