View source for 6fvi


==ASH / PapD-like domain of human CEP192 (PapD-like domain 7)==
<StructureSection load='6fvi' size='340' side='right'caption='[[6fvi]], [[Resolution|resolution]] 1.00&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[6fvi]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6FVI OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6FVI FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene></td></tr>
<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6fvi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6fvi OCA], [http://pdbe.org/6fvi PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6fvi RCSB], [http://www.ebi.ac.uk/pdbsum/6fvi PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6fvi ProSAT]</span></td></tr>
</table>
== Function ==
[[http://www.uniprot.org/uniprot/CE192_HUMAN CE192_HUMAN]] Required for mitotic centrosome maturation and bipolar spindle assembly (PubMed:25042804, PubMed:17980596, PubMed:18207742). Appears to be a major regulator of pericentriolar material (PCM) recruitment, centrosome maturation, and centriole duplication (PubMed:25042804, PubMed:17980596, PubMed:18207742). Centrosome-specific activating scaffold for AURKA and PLK1 (PubMed:25042804).<ref>PMID:17980596</ref> <ref>PMID:18207742</ref> <ref>PMID:25042804</ref>  
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Breugel, M van]]
[[Category: Kovalevskiy, O V]]
[[Category: Ash domain]]
[[Category: Cell cycle]]
[[Category: Centriole]]
[[Category: Centrosome]]
[[Category: Papd-like domain]]