View source for 6ey4


==Periplasmic domain (residues 36-513) of GldM==
<StructureSection load='6ey4' size='340' side='right'caption='[[6ey4]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[6ey4]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Flavobacterium_johnsoniae Flavobacterium johnsoniae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6EY4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6EY4 FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6ey4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6ey4 OCA], [https://pdbe.org/6ey4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6ey4 RCSB], [https://www.ebi.ac.uk/pdbsum/6ey4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6ey4 ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/Q5EGM3_FLAJO Q5EGM3_FLAJO] 
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
Type IX secretion system (T9SS), exclusively present in the Bacteroidetes phylum, has been studied mainly in Flavobacterium johnsoniae and Porphyromonas gingivalis. Among the 18 genes, essential for T9SS function, a group of four, porK-N (P. gingivalis) or gldK-N (F. johnsoniae) belongs to a co-transcribed operon that expresses the T9SS core membrane complex. The central component of this complex, PorM (or GldM), is anchored in the inner membrane by a trans-membrane helix and interacts through the outer membrane PorK-N complex. There is a complete lack of available atomic structures for any component of T9SS, including the PorKLMN complex. Here we report the crystal structure of the GldM and PorM periplasmic domains. Dimeric GldM and PorM, each contain four domains of ~180-A length that span most of the periplasmic space. These and previously reported results allow us to propose a model of the T9SS core membrane complex as well as its functional behavior.

Type IX secretion system PorM and gliding machinery GldM form arches spanning the periplasmic space.,Leone P, Roche J, Vincent MS, Tran QH, Desmyter A, Cascales E, Kellenberger C, Cambillau C, Roussel A Nat Commun. 2018 Jan 30;9(1):429. doi: 10.1038/s41467-017-02784-7. PMID:29382829<ref>PMID:29382829</ref>

From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
<div class="pdbe-citations 6ey4" style="background-color:#fffaf0;"></div>
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Flavobacterium johnsoniae]]
[[Category: Large Structures]]
[[Category: Cambillau C]]
[[Category: Leone P]]
[[Category: Roche J]]
[[Category: Roussel A]]