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==A cryptic RNA-binding domain mediates Syncrip recognition and exosomal partitioning of miRNA targets==
<StructureSection load='6es4' size='340' side='right'caption='[[6es4]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[6es4]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Drosophila_melanogaster Drosophila melanogaster]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6ES4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6ES4 FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.2&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CME:S,S-(2-HYDROXYETHYL)THIOCYSTEINE'>CME</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6es4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6es4 OCA], [https://pdbe.org/6es4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6es4 RCSB], [https://www.ebi.ac.uk/pdbsum/6es4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6es4 ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/A0A0B4KHI4_DROME A0A0B4KHI4_DROME] 
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
Exosomal miRNA transfer is a mechanism for cell-cell communication that is important in the immune response, in the functioning of the nervous system and in cancer. Syncrip/hnRNPQ is a highly conserved RNA-binding protein that mediates the exosomal partition of a set of miRNAs. Here, we report that Syncrip's amino-terminal domain, which was previously thought to mediate protein-protein interactions, is a cryptic, conserved and sequence-specific RNA-binding domain, designated NURR (N-terminal unit for RNA recognition). The NURR domain mediates the specific recognition of a short hEXO sequence defining Syncrip exosomal miRNA targets, and is coupled by a non-canonical structural element to Syncrip's RRM domains to achieve high-affinity miRNA binding. As a consequence, Syncrip-mediated selection of the target miRNAs implies both recognition of the hEXO sequence by the NURR domain and binding of the RRM domains 5' to this sequence. This structural arrangement enables Syncrip-mediated selection of miRNAs with different seed sequences.

A cryptic RNA-binding domain mediates Syncrip recognition and exosomal partitioning of miRNA targets.,Hobor F, Dallmann A, Ball NJ, Cicchini C, Battistelli C, Ogrodowicz RW, Christodoulou E, Martin SR, Castello A, Tripodi M, Taylor IA, Ramos A Nat Commun. 2018 Feb 26;9(1):831. doi: 10.1038/s41467-018-03182-3. PMID:29483512<ref>PMID:29483512</ref>

From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
<div class="pdbe-citations 6es4" style="background-color:#fffaf0;"></div>
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Drosophila melanogaster]]
[[Category: Large Structures]]
[[Category: Ball NJ]]
[[Category: Battistelli C]]
[[Category: Castello A]]
[[Category: Christodoulou E]]
[[Category: Cicchini C]]
[[Category: Dallmann A]]
[[Category: Hobor F]]
[[Category: Martin SR]]
[[Category: Ogrodowicz RW]]
[[Category: Ramos A]]
[[Category: Taylor IA]]
[[Category: Tripodi M]]