View source for 6buv


==Structure of Mycobacterium tuberculosis NadD in complex with inhibitor [(1~{R},2~{R},5~{S})-5-methyl-2-propan-2-yl-cyclohexyl] 2-[3-methyl-2-(phenoxymethyl)benzimidazol-1-yl]ethanoate==
<StructureSection load='6buv' size='340' side='right'caption='[[6buv]], [[Resolution|resolution]] 1.86&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[6buv]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycobacterium_tuberculosis_H37Rv Mycobacterium tuberculosis H37Rv]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6BUV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6BUV FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.86&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=E9A:[(1~{R},2~{R},5~{S})-5-methyl-2-propan-2-yl-cyclohexyl]+2-[3-methyl-2-(phenoxymethyl)benzimidazol-1-yl]ethanoate'>E9A</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6buv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6buv OCA], [https://pdbe.org/6buv PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6buv RCSB], [https://www.ebi.ac.uk/pdbsum/6buv PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6buv ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/NADD_MYCTU NADD_MYCTU] Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD).
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</StructureSection>
[[Category: Large Structures]]
[[Category: Mycobacterium tuberculosis H37Rv]]
[[Category: Korotkov KV]]
[[Category: Osterman AL]]
[[Category: Reed RW]]
[[Category: Rodionova IA]]
[[Category: Sorci L]]