View source for 6bob


==Cryo-EM structure of rat TRPV6* in nanodiscs==
<SX load='6bob' size='340' side='right' viewer='molstar' caption='[[6bob]], [[Resolution|resolution]] 3.90&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[6bob]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6BOB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6BOB FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.9&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6bob FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6bob OCA], [https://pdbe.org/6bob PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6bob RCSB], [https://www.ebi.ac.uk/pdbsum/6bob PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6bob ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/TRPV6_RAT TRPV6_RAT] Calcium selective cation channel probably involved in Ca(2+) uptake in various tissues, including Ca(2+) reabsorption in intestine. The channel is activated by low internal calcium level, probably including intracellular calcium store depletion, and the current exhibits an inward rectification. Inactivation includes both, a rapid Ca(2+)-dependent and a slower Ca(2+)-calmodulin-dependent mechanism, the latter may be regulated by phosphorylation. In vitro, is slowly inhibited by Mg(2+) in a voltage-independent manner. Heteromeric assembly with TRPV5 seems to modify channel properties. TRPV5-TRPV6 heteromultimeric concatemers exhibit voltage-dependent gating (By similarity).[UniProtKB:Q91WD2][UniProtKB:Q9H1D0]<ref>PMID:11287959</ref> 

==See Also==
*[[Ion channels 3D structures|Ion channels 3D structures]]
== References ==
<references/>
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</SX>
[[Category: Large Structures]]
[[Category: Rattus norvegicus]]
[[Category: Grassucci RA]]
[[Category: McGoldrick LL]]
[[Category: Saotome K]]
[[Category: Singh AK]]
[[Category: Sobolevsky AI]]
[[Category: Twomey EC]]
[[Category: Yelshanskaya MV]]