View source for 6b5b


==Cryo-EM structure of the NAIP5-NLRC4-flagellin inflammasome==
<SX load='6b5b' size='340' side='right' viewer='molstar' caption='[[6b5b]], [[Resolution|resolution]] 5.20&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[6b5b]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Legionella_pneumophila Legionella pneumophila] and [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6B5B OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6B5B FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 5.2&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6b5b FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6b5b OCA], [https://pdbe.org/6b5b PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6b5b RCSB], [https://www.ebi.ac.uk/pdbsum/6b5b PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6b5b ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/NLRC4_MOUSE NLRC4_MOUSE] Key component of inflammasomes that indirectly senses specific proteins from pathogenic bacteria and fungi and responds by assembling an inflammasome complex that promotes caspase-1 activation, cytokine production and macrophage pyroptosis. The NLRC4 inflammasome is activated as part of the innate immune response to a range of intracellular bacteria. It senses pathogenic proteins of the type III secretion system (T3SS) and type IV secretion system (T4SS) such as flagellin and PrgJ-like rod proteins via the Naip proteins (Naip1, Naip2 or Naip5): specific Naip proteins recognize and bind pathogenic proteins, driving assembly and activation of the NLRC4 inflammasome. The NLRC4 inflammasome senses Gram-negative bacteria such as L.pneumophila and P.aeruginosa, enteric pathogens S.typhimurium (Salmonella) and S.flexneri and fungal pathogen C.albicans. In intestine, the NLRC4 inflammasome is able to discriminate between commensal and pathogenic bacteria and specifically drives production of interleukin-1 beta (IL1B) in response to infection by Salmonella or P.aeruginosa. In case of L.pneumophila infection the inflammasome acts by activating caspase-7.<ref>PMID:15190255</ref> <ref>PMID:16648853</ref> <ref>PMID:16648852</ref> <ref>PMID:18070936</ref> <ref>PMID:19343209</ref> <ref>PMID:20603313</ref> <ref>PMID:20133635</ref> <ref>PMID:21874021</ref> <ref>PMID:21918512</ref> <ref>PMID:22174673</ref> <ref>PMID:22547706</ref> <ref>PMID:22231517</ref> <ref>PMID:22484733</ref> <ref>PMID:22885697</ref> 

==See Also==
*[[Flagellin 3D structures|Flagellin 3D structures]]
== References ==
<references/>
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</SX>
[[Category: Large Structures]]
[[Category: Legionella pneumophila]]
[[Category: Mus musculus]]
[[Category: Adamson E]]
[[Category: Bourgeois NM]]
[[Category: Chacon P]]
[[Category: Grob P]]
[[Category: Haloupek N]]
[[Category: Hartenian E]]
[[Category: Lind NA]]
[[Category: Lopez-Blanco JR]]
[[Category: Nogales E]]
[[Category: Tenthorey JL]]
[[Category: Vance RE]]