View source for 5yud


==Flagellin derivative in complex with the NLR protein NAIP5==
<SX load='5yud' size='340' side='right' viewer='molstar' caption='[[5yud]], [[Resolution|resolution]] 4.28&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[5yud]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus] and [https://en.wikipedia.org/wiki/Salmonella_enterica_subsp._enterica_serovar_Typhimurium_str._LT2 Salmonella enterica subsp. enterica serovar Typhimurium str. LT2]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5YUD OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5YUD FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 4.28&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ATP:ADENOSINE-5-TRIPHOSPHATE'>ATP</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5yud FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5yud OCA], [https://pdbe.org/5yud PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5yud RCSB], [https://www.ebi.ac.uk/pdbsum/5yud PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5yud ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/BIR1E_MOUSE BIR1E_MOUSE] Sensor component of the NLRC4 inflammasome that specifically recognizes and binds flagellin from pathogenic bacteria such as Legionella or Salmonella. Association of pathogenic bacteria proteins drives in turn drive assembly and activation of the NLRC4 inflammasome, promoting caspase-1 activation, cytokine production and macrophage pyroptosis. The NLRC4 inflammasome is activated as part of the innate immune response to a range of intracellular bacteria. The NLRC4 inflammasome senses Gram-negative bacteria such as L.pneumophila and P.aeruginosa, enteric pathogens S.typhimurium (Salmonella) and S.flexneri. Prevents motor-neuron apoptosis induced by a variety of signals.<ref>PMID:21874021</ref> <ref>PMID:21918512</ref> 

==See Also==
*[[Flagellin 3D structures|Flagellin 3D structures]]
== References ==
<references/>
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[[Category: Large Structures]]
[[Category: Mus musculus]]
[[Category: Salmonella enterica subsp. enterica serovar Typhimurium str. LT2]]
[[Category: Lin GZ]]
[[Category: Wang WG]]
[[Category: Yang F]]
[[Category: Yang XR]]