View source for 5us9


==Human bocavirus 4==
<SX load='5us9' size='340' side='right' viewer='molstar' caption='[[5us9]], [[Resolution|resolution]] 3.00&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[5us9]] is a 60 chain structure with sequence from [https://en.wikipedia.org/wiki/Human_bocavirus_4 Human bocavirus 4]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5US9 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5US9 FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5us9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5us9 OCA], [https://pdbe.org/5us9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5us9 RCSB], [https://www.ebi.ac.uk/pdbsum/5us9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5us9 ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/CAPSD_HBOC4 CAPSD_HBOC4] Capsid proteins self-assembles to form an icosahedral capsid with a T=1 symmetry, about 26 nm in diameter, and consisting of 60 copies of three size variants of the capsid proteins, VP1, and VP3, which differ by the presence of an N-terminal extension in the minor protein VP1. The capsid has a channel at the 5-fold axis and there are densities extending the 5-fold axis into the interior of the capsid (PubMed:28331084). The capsid encapsulates the genomic ssDNA (Probable). Binding to the host receptors also induces capsid rearrangements leading to surface exposure of VP1 N-terminus, specifically its phospholipase A2-like region. The additional N-terminal region of isoform Minor capsid protein VP1, called VP1u, may serve as a lipolytic enzyme to breach the endosomal membrane during entry into host cell and might contribute to virus transport to the nucleus (By similarity).[UniProtKB:Q9PZT0]<ref>PMID:28331084</ref> <ref>PMID:28331084</ref> 
== References ==
<references/>
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[[Category: Human bocavirus 4]]
[[Category: Large Structures]]
[[Category: Agbandje-McKenna M]]
[[Category: Mietzsch M]]