View source for 5ofm


==Crystal structure of human 3-phosphoglycerate dehydrogenase in complex with 5-amino-1-methyl-1H-indole==
<StructureSection load='5ofm' size='340' side='right'caption='[[5ofm]], [[Resolution|resolution]] 1.50&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[5ofm]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5OFM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5OFM FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.5&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=9TT:1-methylindol-5-amine'>9TT</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5ofm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ofm OCA], [https://pdbe.org/5ofm PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5ofm RCSB], [https://www.ebi.ac.uk/pdbsum/5ofm PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5ofm ProSAT]</span></td></tr>
</table>
== Disease ==
[https://www.uniprot.org/uniprot/SERA_HUMAN SERA_HUMAN] Defects in PHGDH are the cause of phosphoglycerate dehydrogenase deficiency (PHGDH deficiency) [MIM:[https://omim.org/entry/601815 601815]. It is characterized by congenital microcephaly, psychomotor retardation, and seizures.
== Function ==
[https://www.uniprot.org/uniprot/SERA_HUMAN SERA_HUMAN] 

==See Also==
*[[Phosphoglycerate dehydrogenase|Phosphoglycerate dehydrogenase]]
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Basle A]]
[[Category: Blackburn TJ]]
[[Category: Cano C]]
[[Category: Curtin NJ]]
[[Category: Noble MEM]]
[[Category: Tucker J]]
[[Category: Unterlass JE]]