View source for 5o1p


==Crystal structure of human aminoadipate semialdehyde synthase, saccharopine dehydrogenase.==
<StructureSection load='5o1p' size='340' side='right'caption='[[5o1p]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[5o1p]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5O1P OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5O1P FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.9&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=DMS:DIMETHYL+SULFOXIDE'>DMS</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5o1p FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5o1p OCA], [https://pdbe.org/5o1p PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5o1p RCSB], [https://www.ebi.ac.uk/pdbsum/5o1p PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5o1p ProSAT]</span></td></tr>
</table>
== Disease ==
[https://www.uniprot.org/uniprot/AASS_HUMAN AASS_HUMAN] Hyperlysinemia;Saccharopinuria. The disease is caused by mutations affecting the gene represented in this entry.  The protein represented in this entry is involved in disease pathogenesis. A selective decrease in mitochondrial NADP(H) levels due to NADK2 mutations causes a deficiency of NADPH-dependent mitochondrial enzymes, such as DECR1 and AASS.<ref>PMID:24847004</ref> 
== Function ==
[https://www.uniprot.org/uniprot/AASS_HUMAN AASS_HUMAN] Bifunctional enzyme that catalyzes the first two steps in lysine degradation. The N-terminal and the C-terminal contain lysine-ketoglutarate reductase and saccharopine dehydrogenase activity, respectively.
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Arrowsmith C]]
[[Category: Arruda P]]
[[Category: Bountra C]]
[[Category: Burgess-Brown N]]
[[Category: Collins P]]
[[Category: Edwards A]]
[[Category: Goubin S]]
[[Category: Kopec J]]
[[Category: Krojer T]]
[[Category: Kupinska K]]
[[Category: Pena IA]]
[[Category: Rembeza E]]
[[Category: Strain-Damerell C]]
[[Category: Talon R]]
[[Category: Velupillai S]]
[[Category: Williams E]]
[[Category: Yue WW]]
[[Category: Von Delft F]]