View source for 5ltu


==Crystal Structure of NUDT4A- Diphosphoinositol polyphosphate phosphohydrolase 2==
<StructureSection load='5ltu' size='340' side='right'caption='[[5ltu]], [[Resolution|resolution]] 2.23&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[5ltu]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5LTU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5LTU FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.23&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5ltu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ltu OCA], [https://pdbe.org/5ltu PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5ltu RCSB], [https://www.ebi.ac.uk/pdbsum/5ltu PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5ltu ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/NUDT4_HUMAN NUDT4_HUMAN] Cleaves a beta-phosphate from the diphosphate groups in PP-InsP5 (diphosphoinositol pentakisphosphate), PP-InsP4 and [PP]2-InsP4 (bisdiphosphoinositol tetrakisphosphate), suggesting that it may play a role in signal transduction. Also able to catalyze the hydrolysis of dinucleoside oligophosphate Ap6A, but not Ap5A. The major reaction products are ADP and p4a from Ap6A. Also able to hydrolyze 5-phosphoribose 1-diphosphate. Does not play a role in U8 snoRNA decapping activity. Binds U8 snoRNA.<ref>PMID:10777568</ref> 
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Arrowsmith CH]]
[[Category: Bountra C]]
[[Category: Burgess-Brown N]]
[[Category: Edwards AM]]
[[Category: Elkins JM]]
[[Category: Huber K]]
[[Category: Mathea S]]
[[Category: Newman J]]
[[Category: Nunez CA]]
[[Category: Siejka P]]
[[Category: Srikannathasan V]]
[[Category: Strain-Damerell C]]
[[Category: Tallant C]]
[[Category: Von Delft F]]