View source for 5ieu


==Crystal Structure of Mycobacterium Tuberculosis ATP-independent Proteasome Activator Tetramer==
<StructureSection load='5ieu' size='340' side='right'caption='[[5ieu]], [[Resolution|resolution]] 2.80&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[5ieu]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5IEU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5IEU FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.8&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5ieu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ieu OCA], [https://pdbe.org/5ieu PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5ieu RCSB], [https://www.ebi.ac.uk/pdbsum/5ieu PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5ieu ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/BPA_MYCTU BPA_MYCTU] Interacts with the core proteasome alpha-subunit (PrcA) through its C-terminal hydrophobic-tyrosine-X motif (HbYX motif). Interaction of Bpa with the proteasome stimulates proteosomal peptidase and casein degradation activity, which suggests Bpa could play a role in the removal of non-native or damaged proteins by influencing the conformation of the proteasome complex upon interaction. Can inhibit degradation of Pup-tagged substrates in vitro by competing with Mpa for association with the proteasome.<ref>PMID:25469515</ref> 
== References ==
<references/>
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</StructureSection>
[[Category: Large Structures]]
[[Category: Mycobacterium tuberculosis]]
[[Category: Bai L]]
[[Category: Darwin KH]]
[[Category: Hu K]]
[[Category: Jastrab JB]]
[[Category: Li H]]
[[Category: Wang T]]