View source for 5bvi


==X-ray Structure of Interferon Regulatory Factor 4 IAD Domain==
<StructureSection load='5bvi' size='340' side='right'caption='[[5bvi]], [[Resolution|resolution]] 2.60&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[5bvi]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5BVI OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5BVI FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.6&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5bvi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5bvi OCA], [https://pdbe.org/5bvi PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5bvi RCSB], [https://www.ebi.ac.uk/pdbsum/5bvi PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5bvi ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/IRF4_MOUSE IRF4_MOUSE] Transcriptional activator. Binds to the interferon-stimulated response element (ISRE) of the MHC class I promoter. Binds the immunoglobulin lambda light chain enhancer, together with PU.1. Probably plays a role in ISRE-targeted signal transduction mechanisms specific to lymphoid cells. Involved in CD8(+) dendritic cell differentiation by forming a complex with the BATF-JUNB heterodimer in immune cells, leading to recognition of AICE sequence (5'-TGAnTCA/GAAA-3'), an immune-specific regulatory element, followed by cooperative binding of BATF and IRF4 and activation of genes.<ref>PMID:22983707</ref> <ref>PMID:22992523</ref> <ref>PMID:22992524</ref> 
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
IRF4 is a unique member of the IRF family playing critical regulatory roles in immune cell development, regulation of obesity-induced inflammation and control of thermogenic gene expression. The ability of IRF4 to control diverse transcriptional programs arises from its proficiency to interact with numerous transcriptional partners. In this study we present the structural characterization of full length IRF4. Using a combination of X-ray and SAXS studies, we reveal unique features of the Interferon Activation Domain (IAD) including a set of beta-sheets and loops that serve as the binding site for PU.1 and also show that unlike other IRF members, IRF4 has a flexible autoinhibitory region. In addition, we have determined the SAXS solution structure of full length IRF4 that together with circular dichroism studies suggest that the linker region is not extended but folds into a domain structure.

Structural Studies of IRF4 Reveal a Flexible Autoinhibitory Region and a Compact Linker Domain.,Remesh SG, Santosh V, Escalante CR J Biol Chem. 2015 Sep 24. pii: jbc.M115.678789. PMID:26405037<ref>PMID:26405037</ref>

From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
<div class="pdbe-citations 5bvi" style="background-color:#fffaf0;"></div>

==See Also==
*[[Interferon regulatory factor|Interferon regulatory factor]]
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Mus musculus]]
[[Category: Escalate CR]]
[[Category: Remesh SG]]