View source for 5aim


==Crystal structure of T138 central eWH domain==
<StructureSection load='5aim' size='340' side='right'caption='[[5aim]], [[Resolution|resolution]] 1.40&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[5aim]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5AIM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5AIM FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.401&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5aim FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5aim OCA], [https://pdbe.org/5aim PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5aim RCSB], [https://www.ebi.ac.uk/pdbsum/5aim PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5aim ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/TFC3_YEAST TFC3_YEAST] TFIIIC mediates tRNA and 5S RNA gene activation by binding to intragenic promoter elements. Upstream of the transcription start site, TFIIIC assembles the initiation complex TFIIIB-TFIIIC-tDNA, which is sufficient for RNA polymerase III recruitment and function. Part of the tauB domain of TFIIIC that binds boxB DNA promoter sites of tRNA and similar genes. TFC3 is essential for cell viability. Cooperates with TFC6 in DNA binding.<ref>PMID:1279682</ref> <ref>PMID:2651441</ref> <ref>PMID:9418847</ref> 

==See Also==
*[[Transcription factor tau|Transcription factor tau]]
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Saccharomyces cerevisiae]]
[[Category: Glatt S]]
[[Category: Male G]]
[[Category: Mueller CW]]