View source for 4oq6


==Crystal Structure of Human MCL-1 Bound to Inhibitor 4-hydroxy-4'-propylbiphenyl-3-carboxylic acid==
<StructureSection load='4oq6' size='340' side='right'caption='[[4oq6]], [[Resolution|resolution]] 1.81&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[4oq6]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4OQ6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4OQ6 FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.81&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=2UV:4-HYDROXY-4-PROPYLBIPHENYL-3-CARBOXYLIC+ACID'>2UV</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4oq6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4oq6 OCA], [https://pdbe.org/4oq6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4oq6 RCSB], [https://www.ebi.ac.uk/pdbsum/4oq6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4oq6 ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/MCL1_HUMAN MCL1_HUMAN] Involved in the regulation of apoptosis versus cell survival, and in the maintenance of viability but not of proliferation. Mediates its effects by interactions with a number of other regulators of apoptosis. Isoform 1 inhibits apoptosis. Isoform 2 promotes apoptosis.<ref>PMID:10766760</ref> 

==See Also==
*[[B-cell lymphoma proteins 3D structures|B-cell lymphoma proteins 3D structures]]
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Kunzer AR]]
[[Category: Park C]]
[[Category: Petros AM]]
[[Category: Song D]]
[[Category: Souers AJ]]
[[Category: Sun C]]
[[Category: Swann SL]]
[[Category: Swinger K]]
[[Category: Wendt MD]]
[[Category: Zhang H]]