View source for 4nmh


==11-beta-HSD1 in complex with a 3,3-Di-methyl-azetidin-2-one==
<StructureSection load='4nmh' size='340' side='right'caption='[[4nmh]], [[Resolution|resolution]] 2.90&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[4nmh]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4NMH OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4NMH FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.9&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=2KG:(4S)-4-(2-METHOXYPHENYL)-3,3-DIMETHYL-1-[3-(METHYLSULFONYL)PHENYL]AZETIDIN-2-ONE'>2KG</scene>, <scene name='pdbligand=NDP:NADPH+DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NDP</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4nmh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4nmh OCA], [https://pdbe.org/4nmh PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4nmh RCSB], [https://www.ebi.ac.uk/pdbsum/4nmh PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4nmh ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/DHI1_MOUSE DHI1_MOUSE] Catalyzes reversibly the conversion of cortisol to the inactive metabolite cortisone.

==See Also==
*[[Hydroxysteroid dehydrogenase 3D structures|Hydroxysteroid dehydrogenase 3D structures]]
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Mus musculus]]
[[Category: Augustin M]]
[[Category: Blake C]]
[[Category: Ertan A]]
[[Category: Gerhardt S]]
[[Category: Kilgour EK]]
[[Category: Krapp S]]
[[Category: McCoull W]]
[[Category: Moore JE]]
[[Category: Newcombe NJ]]
[[Category: Ogg DJ]]
[[Category: Packer MJ]]
[[Category: Rees A]]
[[Category: Revill J]]
[[Category: Scott JS]]
[[Category: Selmi N]]
[[Category: Steinbacher S]]
[[Category: Whittamore PRO]]