View source for 4mro


==Human GKRP bound to AMG-5980 and S6P==
<StructureSection load='4mro' size='340' side='right'caption='[[4mro]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[4mro]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4MRO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4MRO FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.2&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=IOD:IODIDE+ION'>IOD</scene>, <scene name='pdbligand=MG0:2-(4-{4-[(6-AMINOPYRIDIN-3-YL)SULFONYL]PIPERAZIN-1-YL}PHENYL)-1,1,1,3,3,3-HEXAFLUOROPROPAN-2-OL'>MG0</scene>, <scene name='pdbligand=S6P:D-SORBITOL-6-PHOSPHATE'>S6P</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4mro FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4mro OCA], [https://pdbe.org/4mro PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4mro RCSB], [https://www.ebi.ac.uk/pdbsum/4mro PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4mro ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/GCKR_HUMAN GCKR_HUMAN] Inhibits glucokinase by forming an inactive complex with this enzyme.

==See Also==
*[[Glucokinase Regulatory Protein|Glucokinase Regulatory Protein]]
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Ashton KS]]
[[Category: Bartberger MD]]
[[Category: Chen J]]
[[Category: Chmait S]]
[[Category: Cupples R]]
[[Category: Fotsch C]]
[[Category: Galbreath E]]
[[Category: Hale C]]
[[Category: Helmering J]]
[[Category: Jordan SR]]
[[Category: Kunz K]]
[[Category: LLoyd DJ]]
[[Category: Liu L]]
[[Category: Michelsen K]]
[[Category: Nishimura N]]
[[Category: Norman MH]]
[[Category: Pennington LD]]
[[Category: Poon SF]]
[[Category: Sivits G]]
[[Category: St Jean DJ]]
[[Category: Stec MM]]
[[Category: Tamayo N]]
[[Category: Van G]]
[[Category: Yang K]]