View source for 4lki


==The structure of hemagglutinin L226Q mutant from a avian-origin H7N9 influenza virus (A/Anhui/1/2013)==
<StructureSection load='4lki' size='340' side='right'caption='[[4lki]], [[Resolution|resolution]] 2.70&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[4lki]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Influenza_A_virus Influenza A virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4LKI OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4LKI FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.7&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4lki FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4lki OCA], [https://pdbe.org/4lki PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4lki RCSB], [https://www.ebi.ac.uk/pdbsum/4lki PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4lki ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/V5IRV5_9INFA V5IRV5_9INFA] 
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
An avian-origin human-infecting influenza (H7N9) virus was recently identified in China. We have evaluated the viral hemagglutinin (HA) receptor-binding properties of two human H7N9 isolates, A/Shanghai/1/2013 (SH-H7N9) (containing the avian-signature residue Gln(226)) and A/Anhui/1/2013 (AH-H7N9) (containing the mammalian-signature residue Leu(226)). We found that SH-H7N9 HA preferentially binds the avian receptor analog, whereas AH-H7N9 HA binds both avian and human receptor analogs. Furthermore, an AH-H7N9 mutant HA (Leu(226) --&gt; Gln) was found to exhibit dual receptor-binding property, indicating that other amino acid substitutions contribute to the receptor-binding switch. The structures of SH-H7N9 HA, AH-H7N9 HA, and its mutant in complex with either avian or human receptor analogs show how AH-H7N9 can bind human receptors while still retaining the avian receptor-binding property.

Structures and receptor binding of hemagglutinins from human-infecting H7N9 influenza viruses.,Shi Y, Zhang W, Wang F, Qi J, Wu Y, Song H, Gao F, Bi Y, Zhang Y, Fan Z, Qin C, Sun H, Liu J, Haywood J, Liu W, Gong W, Wang D, Shu Y, Wang Y, Yan J, Gao GF Science. 2013 Oct 11;342(6155):243-7. doi: 10.1126/science.1242917. Epub 2013 Sep, 5. PMID:24009358<ref>PMID:24009358</ref>

From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
<div class="pdbe-citations 4lki" style="background-color:#fffaf0;"></div>

==See Also==
*[[Hemagglutinin 3D structures|Hemagglutinin 3D structures]]
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Influenza A virus]]
[[Category: Large Structures]]
[[Category: Fan Z]]
[[Category: Gao F]]
[[Category: Gao GF]]
[[Category: Gong W]]
[[Category: Qi J]]
[[Category: Shi Y]]
[[Category: Shu Y]]
[[Category: Song H]]
[[Category: Wang D]]
[[Category: Wang F]]
[[Category: Wang Y]]
[[Category: Wu Y]]
[[Category: Yan J]]
[[Category: Zhang W]]
[[Category: Zhang Y]]