View source for 4lct


==Crystal Structure and Versatile Functional Roles of the COP9 Signalosome Subunit 1==
<StructureSection load='4lct' size='340' side='right'caption='[[4lct]], [[Resolution|resolution]] 2.70&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[4lct]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Arabidopsis_thaliana Arabidopsis thaliana]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4LCT OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4LCT FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.7&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4lct FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4lct OCA], [https://pdbe.org/4lct PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4lct RCSB], [https://www.ebi.ac.uk/pdbsum/4lct PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4lct ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/CSN1_ARATH CSN1_ARATH] Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes such as photomorphogenesis and auxin and jasmonate responses. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF. It is involved in repression of photomorphogenesis in darkness by regulating the activity of COP1-containing Ubl ligase complexes. The complex is also required for degradation of IAA6 by regulating the activity of the Ubl ligase SCF-TIR complex. In the complex, it plays a central role in CSN assembly.<ref>PMID:8689678</ref> <ref>PMID:11337587</ref> 

==See Also==
*[[Signalosome|Signalosome]]
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Arabidopsis thaliana]]
[[Category: Large Structures]]
[[Category: Borgmann M]]
[[Category: Lee J-H]]
[[Category: Li J]]
[[Category: Naumann M]]
[[Category: Schweitzer K]]
[[Category: Wu H]]
[[Category: Yi L]]