View source for 4jdm


==Secreted Chlamydial Protein PGP3, full-length==
<StructureSection load='4jdm' size='340' side='right'caption='[[4jdm]], [[Resolution|resolution]] 3.10&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[4jdm]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Chlamydia_trachomatis_D-LC Chlamydia trachomatis D-LC]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4JDM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4JDM FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.1&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4jdm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4jdm OCA], [https://pdbe.org/4jdm PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4jdm RCSB], [https://www.ebi.ac.uk/pdbsum/4jdm PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4jdm ProSAT]</span></td></tr>
</table>
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
Chlamydia trachomatis infection is the most common sexually transmitted bacterial disease. Left untreated, it can lead to ectopic pregnancy, pelvic inflammatory disease, and infertility. Here we present the structure of the secreted C. trachomatis protein Pgp3, an immunodominant antigen and putative virulence factor. The ~84 kDa Pgp3 homotrimer, encoded on a cryptic plasmid, consists of globular N- and C-terminal assemblies connected by a triple helical coiled-coil (THCC). The C-terminal domains (CTDs) possess folds similar to members of the tumor necrosis factor (TNF) family of cytokines. The closest Pgp3 CTD structural homologs include a lectin from Burkholderia cenocepacia, the C1q component of complement, and a portion of the Bacillus anthracis spore surface protein BclA, all of which play roles in bioadhesion. The N-terminal domain (NTD) consists of a concatenation of structural motifs typically found in trimeric viral proteins. The central parallel THCC contains an unusual alternating pattern of apolar and polar residue pairs that generate a rare right-handed superhelical twist. The unique architecture of Pgp3 provides the basis for understanding its role in chlamydial pathogenesis and serves as the platform for its optimization as a potential vaccine antigen candidate.

Structure of the Chlamydia trachomatis Immunodominant Antigen Pgp3.,Galaleldeen A, Taylor AB, Chen D, Schuermann JP, Holloway SP, Hou S, Gong S, Zhong G, Hart PJ J Biol Chem. 2013 May 23. PMID:23703617<ref>PMID:23703617</ref>

From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
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== References ==
<references/>
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</StructureSection>
[[Category: Chlamydia trachomatis D-LC]]
[[Category: Large Structures]]
[[Category: Chen D]]
[[Category: Galaleldeen A]]
[[Category: Hart PJ]]
[[Category: Holloway SP]]
[[Category: Taylor AB]]
[[Category: Zhong G]]