View source for 4hl8


==Re-refinement of the vault ribonucleoprotein particle==
<StructureSection load='4hl8' size='340' side='right'caption='[[4hl8]], [[Resolution|resolution]] 3.50&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[4hl8]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4HL8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4HL8 FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.5&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4hl8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4hl8 OCA], [https://pdbe.org/4hl8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4hl8 RCSB], [https://www.ebi.ac.uk/pdbsum/4hl8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4hl8 ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/MVP_RAT MVP_RAT] Required for normal vault structure. Vaults are multi-subunit structures that may act as scaffolds for proteins involved in signal transduction. Vaults may also play a role in nucleo-cytoplasmic transport. Down-regulates INFG-mediated STAT1 signaling and subsequent activation of JAK. Down-regulates SRC activity and signaling through MAP kinases (By similarity).
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</StructureSection>
[[Category: Large Structures]]
[[Category: Rattus norvegicus]]
[[Category: Casanas A]]
[[Category: Fita I]]
[[Category: Guerra P]]
[[Category: Pous J]]
[[Category: Querol-Audi J]]
[[Category: Tanaka H]]
[[Category: Tsukihara T]]
[[Category: Verdaguer V]]