View source for 4fvu


==Structural basis for the dsRNA specificity of the Lassa virus NP exonuclease==
<StructureSection load='4fvu' size='340' side='right'caption='[[4fvu]], [[Resolution|resolution]] 2.91&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[4fvu]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Lassa_virus_Josiah Lassa virus Josiah] and [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4FVU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4FVU FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.91&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4fvu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4fvu OCA], [https://pdbe.org/4fvu PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4fvu RCSB], [https://www.ebi.ac.uk/pdbsum/4fvu PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4fvu ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/NCAP_LASSJ NCAP_LASSJ] Encapsidates the genome, protecting it from nucleases. The encapsidated genomic RNA is termed the nucleocapsid (NC). Serves as template for viral transcription and replication. The increased presence of protein N in host cell does not seem to trigger the switch from transcription to replication as observed in other negative strain RNA viruses. Disables the host innate defense by interfering with beta interferon (IFN-beta) production. Strongly inhibits the nuclear translocation of IRF3, a protein involved in IFN activation pathway. Also inhibits the activation of IFN-beta and IRF3-dependent promoters (By similarity).

==See Also==
*[[Nucleoprotein 3D structures|Nucleoprotein 3D structures]]
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Lassa virus Josiah]]
[[Category: Synthetic construct]]
[[Category: Hastie KM]]
[[Category: King LB]]
[[Category: Saphire EO]]
[[Category: Zandonatti MA]]