View source for 4fea


==Crystal structure of CASPASE-7 in Complex with allosteric inhibitor==
<StructureSection load='4fea' size='340' side='right'caption='[[4fea]], [[Resolution|resolution]] 3.79&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[4fea]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4FEA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4FEA FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.79&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=0TE:CHLORO{METHYL+HYDROGENATO(3-)-KAPPA~2~N,S+[PYRIDIN-2-YL(PYRIDIN-2(1H)-YLIDENE-KAPPAN)METHYL]CARBONODITHIOHYDRAZONATE}COPPER'>0TE</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4fea FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4fea OCA], [https://pdbe.org/4fea PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4fea RCSB], [https://www.ebi.ac.uk/pdbsum/4fea PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4fea ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/CASP7_HUMAN CASP7_HUMAN] Involved in the activation cascade of caspases responsible for apoptosis execution. Cleaves and activates sterol regulatory element binding proteins (SREBPs). Proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-|-Gly-217' bond. Overexpression promotes programmed cell death.

==See Also==
*[[Caspase 3D structures|Caspase 3D structures]]
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Kabaleeswaran V]]