View source for 4exm


==The crystal structure of an engineered phage lysin containing the binding domain of pesticin and the killing domain of T4-lysozyme==
<StructureSection load='4exm' size='340' side='right'caption='[[4exm]], [[Resolution|resolution]] 2.60&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[4exm]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_virus_T4 Escherichia virus T4] and [https://en.wikipedia.org/wiki/Yersinia_pestis Yersinia pestis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4EXM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4EXM FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.6&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4exm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4exm OCA], [https://pdbe.org/4exm PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4exm RCSB], [https://www.ebi.ac.uk/pdbsum/4exm PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4exm ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/ENLYS_BPT4 ENLYS_BPT4] Endolysin with lysozyme activity that degrades host peptidoglycans and participates with the holin and spanin proteins in the sequential events which lead to the programmed host cell lysis releasing the mature viral particles. Once the holin has permeabilized the host cell membrane, the endolysin can reach the periplasm and break down the peptidoglycan layer.<ref>PMID:22389108</ref> [https://www.uniprot.org/uniprot/Q57159_YERPE Q57159_YERPE] 

==See Also==
*[[Lysozyme 3D structures|Lysozyme 3D structures]]
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Escherichia virus T4]]
[[Category: Large Structures]]
[[Category: Yersinia pestis]]
[[Category: Barnard TJ]]
[[Category: Buchanan SK]]
[[Category: Fairman JW]]
[[Category: Lukacik P]]
[[Category: Noinaj N]]
[[Category: Seddiki N]]