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==The complete structure of CorA magnesium transporter from Methanocaldococcus jannaschii==
<StructureSection load='4ev6' size='340' side='right'caption='[[4ev6]], [[Resolution|resolution]] 3.20&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[4ev6]] is a 5 chain structure with sequence from [https://en.wikipedia.org/wiki/Methanocaldococcus_jannaschii_DSM_2661 Methanocaldococcus jannaschii DSM 2661]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4EV6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4EV6 FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.2&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=UMQ:UNDECYL-MALTOSIDE'>UMQ</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4ev6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ev6 OCA], [https://pdbe.org/4ev6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4ev6 RCSB], [https://www.ebi.ac.uk/pdbsum/4ev6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4ev6 ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/CORA_METJA CORA_METJA] Mediates influx of magnesium ions.<ref>PMID:9573171</ref> 
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
Despite the importance of Mg(2+) for numerous cellular activities, the mechanisms underlying its import and homeostasis are poorly understood. The CorA family is ubiquitous and is primarily responsible for Mg(2+) transport. However, the key questions-such as, the ion selectivity, the transport pathway, and the gating mechanism-have remained unanswered for this protein family. We present a 3.2 A resolution structure of the archaeal CorA from Methanocaldococcus jannaschii, which is a unique complete structure of a CorA protein and reveals the organization of the selectivity filter, which is composed of the signature motif of this family. The structure reveals that polar residues facing the channel coordinate a partially hydrated Mg(2+) during the transport. Based on these findings, we propose a unique gating mechanism involving a helical turn upon the binding of Mg(2+) to the regulatory intracellular binding sites, and thus converting a polar ion passage into a narrow hydrophobic pore. Because the amino acids involved in the uptake, transport, and gating are all conserved within the entire CorA family, we believe this mechanism is general for the whole family including the eukaryotic homologs.

Structural insights into the mechanisms of Mg2+ uptake, transport, and gating by CorA.,Guskov A, Nordin N, Reynaud A, Engman H, Lundback AK, Jong AJ, Cornvik T, Phua T, Eshaghi S Proc Natl Acad Sci U S A. 2012 Nov 6;109(45):18459-64. doi:, 10.1073/pnas.1210076109. Epub 2012 Oct 22. PMID:23091000<ref>PMID:23091000</ref>

From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
<div class="pdbe-citations 4ev6" style="background-color:#fffaf0;"></div>
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Methanocaldococcus jannaschii DSM 2661]]
[[Category: Cornvik T]]
[[Category: Engman H]]
[[Category: Eshaghi S]]
[[Category: Guskov A]]
[[Category: Jong AJO]]
[[Category: Lundback A-K]]
[[Category: Nordin N]]
[[Category: Phua T]]
[[Category: Reynaud A]]