View source for 4akv


==Crystal structure of human sorting nexin 33 (SNX33)==
<StructureSection load='4akv' size='340' side='right'caption='[[4akv]], [[Resolution|resolution]] 2.65&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[4akv]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4AKV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4AKV FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.651&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4akv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4akv OCA], [https://pdbe.org/4akv PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4akv RCSB], [https://www.ebi.ac.uk/pdbsum/4akv PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4akv ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/SNX33_HUMAN SNX33_HUMAN] Plays a role in the reorganization of the cytoskeleton, endocytosis and cellular vesicle trafficking via its interactions with membranes, WASL, DNM1 and DNM2. Acts both during interphase and at the end of mitotic cell divisions. Required for efficient progress through mitosis and cytokinesis. Required for normal formation of the cleavage furrow at the end of mitosis. Modulates endocytosis of cell-surface proteins, such as APP and PRNP; this then modulates the secretion of APP and PRNP peptides. Promotes membrane tubulation (in vitro). May promote the formation of macropinosomes.<ref>PMID:18353773</ref> <ref>PMID:18419754</ref> <ref>PMID:19487689</ref> <ref>PMID:20964629</ref> <ref>PMID:21048941</ref> <ref>PMID:22718350</ref> 

==See Also==
*[[Sorting nexin 3D structures|Sorting nexin 3D structures]]
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Arrowsmith C]]
[[Category: Bountra C]]
[[Category: Edwards A]]
[[Category: Filippakopoulos P]]
[[Category: Froese DS]]
[[Category: Krojer T]]
[[Category: Muniz JRC]]
[[Category: Oberholzer A]]
[[Category: Shrestha L]]
[[Category: Weigelt J]]
[[Category: Yue WW]]
[[Category: Von Delft F]]