View source for 3utc


==Ec_IspH in complex with (E)-4-hydroxybut-3-enyl diphosphate==
<StructureSection load='3utc' size='340' side='right'caption='[[3utc]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[3utc]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli_K-12 Escherichia coli K-12]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3UTC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3UTC FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.9&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=0JX:(3E)-4-HYDROXYBUT-3-EN-1-YL+TRIHYDROGEN+DIPHOSPHATE'>0JX</scene>, <scene name='pdbligand=SF4:IRON/SULFUR+CLUSTER'>SF4</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3utc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3utc OCA], [https://pdbe.org/3utc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3utc RCSB], [https://www.ebi.ac.uk/pdbsum/3utc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3utc ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/ISPH_ECOLI ISPH_ECOLI] Converts 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Is also involved in penicillin tolerance and control of the stringent response. Seems to directly or indirectly interact with RelA to maintain it in an inactive form during normal growth.<ref>PMID:19569147</ref> <ref>PMID:20080550</ref> <ref>PMID:22137895</ref> 

==See Also==
*[[4-hydroxy-3-methylbut-2-enyl diphosphate reductase 3D structures|4-hydroxy-3-methylbut-2-enyl diphosphate reductase 3D structures]]
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Escherichia coli K-12]]
[[Category: Large Structures]]
[[Category: Bacher A]]
[[Category: Eisenreich W]]
[[Category: Groll M]]
[[Category: Li K]]
[[Category: Oldfield E]]
[[Category: Schulz C]]
[[Category: Span I]]
[[Category: Wang K]]
[[Category: Wang W]]
[[Category: Zhang Y]]