View source for 3rc8


==Human Mitochondrial Helicase Suv3 in Complex with Short RNA Fragment==
<StructureSection load='3rc8' size='340' side='right'caption='[[3rc8]], [[Resolution|resolution]] 2.90&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[3rc8]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3RC8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3RC8 FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.9&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3rc8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3rc8 OCA], [https://pdbe.org/3rc8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3rc8 RCSB], [https://www.ebi.ac.uk/pdbsum/3rc8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3rc8 ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/SUV3_HUMAN SUV3_HUMAN] Major helicase player in mitochondrial RNA metabolism. Component of the mitochondrial degradosome (mtEXO) complex, that degrades 3' overhang double-stranded RNA with a 3'-to-5' directionality in an ATP-dependent manner. ATPase and ATP-dependent multisubstrate helicase, able to unwind double-stranded (ds) DNA and RNA, and RNA/DNA heteroduplexes in the 5'-to-3' direction. Plays a role in the RNA surveillance system in mitochondria; regulates the stability of mature mRNAs, the removal of aberrantly formed mRNAs and the rapid degradation of non coding processing intermediates. Also implicated in recombination and chromatin maintenance pathways. May protect cells from apoptosis. Associates with mitochondrial DNA.<ref>PMID:12466530</ref> <ref>PMID:15096047</ref> <ref>PMID:17352692</ref> <ref>PMID:17961633</ref> <ref>PMID:18678873</ref> <ref>PMID:19509288</ref> <ref>PMID:19864255</ref> 

==See Also==
*[[Helicase 3D structures|Helicase 3D structures]]
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Dauter M]]
[[Category: Dauter Z]]
[[Category: Jedrzejczak R]]
[[Category: Stepien P]]
[[Category: Szczesny R]]
[[Category: Wang J]]