View source for 3r3l


==Structure of NP protein from Lassa AV strain==
<StructureSection load='3r3l' size='340' side='right'caption='[[3r3l]], [[Resolution|resolution]] 2.45&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[3r3l]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Lassa_mammarenavirus Lassa mammarenavirus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3R3L OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3R3L FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.449&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3r3l FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3r3l OCA], [https://pdbe.org/3r3l PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3r3l RCSB], [https://www.ebi.ac.uk/pdbsum/3r3l PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3r3l ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/Q9DQX7_LASV Q9DQX7_LASV] Encapsidates the genome, protecting it from nucleases. The encapsidated genomic RNA is termed the nucleocapsid (NC). Serves as template for viral transcription and replication. The increased presence of protein N in host cell does not seem to trigger the switch from transcription to replication as observed in other negative strain RNA viruses. Through the interaction with host IKBKE, strongly inhibits the phosphorylation and nuclear translocation of host IRF3, a protein involved in interferon activation pathway, leading to the inhibition of interferon-beta and IRF3-dependent promoters activation. Encodes also a functional 3'-5' exoribonuclease that degrades preferentially dsRNA substrates and therby participates in the suppression of interferon induction.[HAMAP-Rule:MF_04085]

==See Also==
*[[Nucleoprotein 3D structures|Nucleoprotein 3D structures]]
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Lassa mammarenavirus]]
[[Category: Betzel C]]
[[Category: Brunotte L]]
[[Category: Gunther S]]
[[Category: Perbandt M]]