View source for 3mrf


==Crystal Structure of MHC class I HLA-A2 molecule complexed with EBV bmlf1-280-288 nonapeptide T4P variant==
<StructureSection load='3mrf' size='340' side='right'caption='[[3mrf]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[3mrf]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Human_gammaherpesvirus_4 Human gammaherpesvirus 4]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3MRF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3MRF FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.3&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3mrf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3mrf OCA], [https://pdbe.org/3mrf PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3mrf RCSB], [https://www.ebi.ac.uk/pdbsum/3mrf PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3mrf ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/ICP27_EBVG ICP27_EBVG] Promotes the nuclear export of a subset of early and late viral mRNAs by interacting with mRNAs and cellular export proteins. Additionally may prevent the establishment of cellular antiviral state, by acting as an alternative splicing factor for cellular RNAs such as STAT1, resulting in a STAT1 mRNA incapable of producing the STAT1alpha isoform (By similarity).

==See Also==
*[[Beta-2 microglobulin 3D structures|Beta-2 microglobulin 3D structures]]
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Human gammaherpesvirus 4]]
[[Category: Large Structures]]
[[Category: Bonneville M]]
[[Category: Chouquet A]]
[[Category: Debeaupuis E]]
[[Category: Echasserieau K]]
[[Category: Gras S]]
[[Category: Housset D]]
[[Category: Saulquin X]]
[[Category: Trudel E]]