View source for 3miw


==Crystal Structure of Rotavirus NSP4==
<StructureSection load='3miw' size='340' side='right'caption='[[3miw]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[3miw]] is a 10 chain structure with sequence from [https://en.wikipedia.org/wiki/Human_rotavirus_G4_strain_St._Thomas_3 Human rotavirus G4 strain St. Thomas 3]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3MIW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3MIW FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.5&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3miw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3miw OCA], [https://pdbe.org/3miw PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3miw RCSB], [https://www.ebi.ac.uk/pdbsum/3miw PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3miw ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/NSP4_ROTHT NSP4_ROTHT] Involved in virus morphogenesis. Functions as a receptor for the immature double-layered inner capsid particle (ICP) which transiently buds into the lumen of the rough endoplasmic reticulum during viral maturation (By similarity).  Enterotoxin that causes a phospholipase C-dependent elevation of the intracellular calcium concentration in host intestinal mucosa cells. Increased concentration of intracellular calcium disrupts the cytoskeleton and the tight junctions, raising the paracellular permeability. Potentiates chloride ion secretion through a calcium ion-dependent signaling pathway, inducing age-dependent diarrhea. To perform this enterotoxigenic role in vivo, NSP4 is probably released from infected enterocytes in a soluble form capable of diffusing within the intestinal lumen and interacting with the plasma membrane receptors on neighboring epithelial cells. Possible receptors for NSP4 are alpha-1/beta-1 and alpha-2/beta-1 integrin heterodimers (By similarity).
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</StructureSection>
[[Category: Human rotavirus G4 strain St. Thomas 3]]
[[Category: Large Structures]]
[[Category: Chacko AR]]
[[Category: Dodson EJ]]
[[Category: Rao DC]]
[[Category: Read RJ]]
[[Category: Suguna K]]