View source for 3j6c


==Cryo-EM structure of MAVS CARD filament==
<SX load='3j6c' size='340' side='right' viewer='molstar' caption='[[3j6c]], [[Resolution|resolution]] 9.60&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[3j6c]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3J6C OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3J6C FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 9.6&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3j6c FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3j6c OCA], [https://pdbe.org/3j6c PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3j6c RCSB], [https://www.ebi.ac.uk/pdbsum/3j6c PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3j6c ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/MAVS_HUMAN MAVS_HUMAN] Required for innate immune defense against viruses. Acts downstream of DDX58/RIG-I and IFIH1/MDA5, which detect intracellular dsRNA produced during viral replication, to coordinate pathways leading to the activation of NF-kappa-B, IRF3 and IRF7, and to the subsequent induction of antiviral cytokines such as IFN-beta and RANTES (CCL5). Peroxisomal and mitochondrial MAVS act sequentially to create an antiviral cellular state. Upon viral infection, peroxisomal MAVS induces the rapid interferon-independent expression of defense factors that provide short-term protection, whereas mitochondrial MAVS activates an interferon-dependent signaling pathway with delayed kinetics, which amplifies and stabilizes the antiviral response. May activate the same pathways following detection of extracellular dsRNA by TLR3. May protect cells from apoptosis.<ref>PMID:16125763</ref> <ref>PMID:16153868</ref> <ref>PMID:16177806</ref> <ref>PMID:16127453</ref> <ref>PMID:19631370</ref> <ref>PMID:20451243</ref> 
== References ==
<references/>
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[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Borkowski B]]
[[Category: Chen ZJ]]
[[Category: He X]]
[[Category: Hou F]]
[[Category: Huang LJ]]
[[Category: Jiang Q-X]]
[[Category: Xu H]]
[[Category: Yu Z]]
[[Category: Zhang X]]
[[Category: Zheng H]]
[[Category: De la Cruz MJ]]