View source for 3foh


==Fitting of gp18M crystal structure into 3D cryo-EM reconstruction of bacteriophage T4 extended tail==
<SX load='3foh' size='340' side='right' viewer='molstar' caption='[[3foh]], [[Resolution|resolution]] 15.00&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[3foh]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_virus_T4 Escherichia virus T4]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3FOH OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3FOH FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 15&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3foh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3foh OCA], [https://pdbe.org/3foh PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3foh RCSB], [https://www.ebi.ac.uk/pdbsum/3foh PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3foh ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/TSP_BPT4 TSP_BPT4] Structural component of the bacteriophage tail which consists of a contractile sheath, a tube and a baseplate. The central cylindrical segment of the tail consists of a rigid tube, composed of multiple copies of gp19, surrounded by the outer contractile sheath assembled from gp18 subunits. A total of 138 copies of gp18 arranged into 23 hexameric rings constitutes the sheath. During infection, contraction of the sheath drives the central tube through the host outer membrane, creating a channel for DNA ejection from the capsid into the host cell.<ref>PMID:14625682</ref> 
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/fo/3foh_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3foh ConSurf].
<div style="clear:both"></div>
== References ==
<references/>
__TOC__
</SX>
[[Category: Escherichia virus T4]]
[[Category: Large Structures]]
[[Category: Aksyuk AA]]
[[Category: Kostyuchenko VA]]
[[Category: Kurochkina LP]]
[[Category: Leiman PG]]
[[Category: Mesyanzhinov VV]]
[[Category: Rossmann MG]]
[[Category: Shneider MM]]