View source for 3ebf


==Structure of inhibited murine iNOS oxygenase domain==
<StructureSection load='3ebf' size='340' side='right'caption='[[3ebf]], [[Resolution|resolution]] 2.29&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[3ebf]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3EBF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3EBF FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.29&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=332:(3R)-3-[(1,2,3,4-TETRAHYDROISOQUINOLIN-7-YLOXY)METHYL]-2,3-DIHYDROTHIENO[2,3-F][1,4]OXAZEPIN-5-AMINE'>332</scene>, <scene name='pdbligand=H4B:5,6,7,8-TETRAHYDROBIOPTERIN'>H4B</scene>, <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3ebf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ebf OCA], [https://pdbe.org/3ebf PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3ebf RCSB], [https://www.ebi.ac.uk/pdbsum/3ebf PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3ebf ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/NOS2_MOUSE NOS2_MOUSE] Produces nitric oxide (NO) which is a messenger molecule with diverse functions throughout the body. In macrophages, NO mediates tumoricidal and bactericidal actions. Also has nitrosylase activity and mediates cysteine S-nitrosylation of cytoplasmic target proteins such COX2.<ref>PMID:16373578</ref> 
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/eb/3ebf_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3ebf ConSurf].
<div style="clear:both"></div>

==See Also==
*[[Nitric Oxide Synthase 3D structures|Nitric Oxide Synthase 3D structures]]
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Mus musculus]]
[[Category: Aberg A]]
[[Category: Andersson G]]
[[Category: Andrews G]]
[[Category: Arvai AS]]
[[Category: Cheshire DR]]
[[Category: Connolly S]]
[[Category: Crane BR]]
[[Category: Garcin ED]]
[[Category: Gensmantel NP]]
[[Category: Getzoff ED]]
[[Category: Hamley PJ]]
[[Category: Kroeger MD]]
[[Category: Mallinder PR]]
[[Category: Mete A]]
[[Category: Nicholls DJ]]
[[Category: Rosenfeld RJ]]
[[Category: St-Gallay SA]]
[[Category: Stuehr DJ]]
[[Category: Tainer JA]]
[[Category: Tinker AC]]
[[Category: Wallace AV]]