View source for 2ypd


==Crystal structure of the Jumonji domain of human Jumonji domain containing 1C protein==
<StructureSection load='2ypd' size='340' side='right'caption='[[2ypd]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[2ypd]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2YPD OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2YPD FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.1&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EMT:2-(ETHYLMERCURI-THIO)-BENZOIC+ACID'>EMT</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2ypd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ypd OCA], [https://pdbe.org/2ypd PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2ypd RCSB], [https://www.ebi.ac.uk/pdbsum/2ypd PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2ypd ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/JHD2C_HUMAN JHD2C_HUMAN] Probable histone demethylase that specifically demethylates 'Lys-9' of histone H3, thereby playing a central role in histone code. Demethylation of Lys residue generates formaldehyde and succinate. May be involved in hormone-dependent transcriptional activation, by participating in recruitment to androgen-receptor target genes (By similarity).
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Arrowsmith CH]]
[[Category: Berridge G]]
[[Category: Bountra C]]
[[Category: Burgess-Brown N]]
[[Category: Coutandin D]]
[[Category: Edwards A]]
[[Category: Froese S]]
[[Category: Goubin S]]
[[Category: Johansson C]]
[[Category: Krojer T]]
[[Category: Oppermann U]]
[[Category: Strain-Damerell C]]
[[Category: Vollmar M]]
[[Category: Williams E]]
[[Category: Von Delft F]]