View source for 2pq5


==Crystal structure of Dual specificity protein phosphatase 13 (DUSP13)==
<StructureSection load='2pq5' size='340' side='right'caption='[[2pq5]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[2pq5]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2PQ5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2PQ5 FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.3&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2pq5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2pq5 OCA], [https://pdbe.org/2pq5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2pq5 RCSB], [https://www.ebi.ac.uk/pdbsum/2pq5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2pq5 ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/DS13B_HUMAN DS13B_HUMAN] Dual specificity phosphatase that dephosphorylates MAPK8/JNK and MAPK14/p38, but not MAPK1/ERK2, in vitro. Exhibits intrinsic phosphatase activity towards both phospho-seryl/threonyl and -tyrosyl residues, with similar specific activities in vitro.<ref>PMID:21360282</ref> 
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/pq/2pq5_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2pq5 ConSurf].
<div style="clear:both"></div>

==See Also==
*[[Dual specificity phosphatase 3D structures|Dual specificity phosphatase 3D structures]]
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Arrowsmith CH]]
[[Category: Barr A]]
[[Category: Berridge G]]
[[Category: Bunkoczi G]]
[[Category: Burgess-Brown N]]
[[Category: Edwards A]]
[[Category: Knapp S]]
[[Category: Niesen F]]
[[Category: Pantic N]]
[[Category: Pike ACW]]
[[Category: Salah E]]
[[Category: Savitsky P]]
[[Category: Sundstrom M]]
[[Category: Ugochukwu E]]
[[Category: Uppenberg J]]
[[Category: Weigelt J]]
[[Category: Von Delft F]]