View source for 2mog


==Solution structure of the terminal Ig-like domain from Leptospira interrogans LigB==
<StructureSection load='2mog' size='340' side='right'caption='[[2mog]]' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[2mog]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Leptospira_interrogans Leptospira interrogans]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2MOG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2MOG FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2mog FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2mog OCA], [https://pdbe.org/2mog PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2mog RCSB], [https://www.ebi.ac.uk/pdbsum/2mog PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2mog ProSAT]</span></td></tr>
</table>
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
A number of surface proteins specific to pathogenic strains of Leptospira have been identified. The Lig protein family has shown promise as a marker in typing leptospiral isolates for pathogenesis and as an antigen in vaccines. We used NMR spectroscopy to solve the solution structure of the twelfth immunoglobulin-like (Ig-like) repeat domain from LigB (LigB-12). The fold is similar to that of other bacterial Ig-like domains and comprised mainly of beta-strands that form a beta-sandwich based on a Greek-key folding arrangement. Based on sequence analysis and conservation of structurally important residues, homology models for the other LigB Ig-like domains were generated. The set of LigB models illustrates the electrostatic differences between the domains as well as the possible interactions between neighboring domains. Understanding the structure of the extracellular portion of LigB and related proteins is important for developing diagnostic methods and new therapeutics directed toward leptospirosis.

NMR Solution Structure of the Terminal Immunoglobulin-like Domain from the Leptospira Host-Interacting Outer Membrane Protein, LigB.,Ptak CP, Hsieh CL, Lin YP, Maltsev AS, Raman R, Sharma Y, Oswald RE, Chang YF Biochemistry. 2014 Aug 4. PMID:25068811<ref>PMID:25068811</ref>

From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
<div class="pdbe-citations 2mog" style="background-color:#fffaf0;"></div>
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Leptospira interrogans]]
[[Category: Chang Y]]
[[Category: Hsieh C]]
[[Category: Lin Y]]
[[Category: Maltsev AS]]
[[Category: Oswald RE]]
[[Category: Ptak CP]]
[[Category: Raman R]]
[[Category: Sharma Y]]