View source for 2mgu


==Structure of the complex between calmodulin and the binding domain of HIV-1 matrix protein==
<StructureSection load='2mgu' size='340' side='right'caption='[[2mgu]]' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[2mgu]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Human_immunodeficiency_virus_1 Human immunodeficiency virus 1] and [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2MGU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2MGU FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2mgu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2mgu OCA], [https://pdbe.org/2mgu PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2mgu RCSB], [https://www.ebi.ac.uk/pdbsum/2mgu PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2mgu ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/CALM1_RAT CALM1_RAT] Calmodulin mediates the control of a large number of enzymes, ion channels, aquaporins and other proteins through calcium-binding. Among the enzymes to be stimulated by the calmodulin-calcium complex are a number of protein kinases and phosphatases. Together with CCP110 and centrin, is involved in a genetic pathway that regulates the centrosome cycle and progression through cytokinesis. Mediates calcium-dependent inactivation of CACNA1C. Positively regulates calcium-activated potassium channel activity of KCNN2.[UniProtKB:P62158]

==See Also==
*[[Calmodulin 3D structures|Calmodulin 3D structures]]
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</StructureSection>
[[Category: Human immunodeficiency virus 1]]
[[Category: Large Structures]]
[[Category: Rattus norvegicus]]
[[Category: Saad J]]
[[Category: Samal A]]
[[Category: Vlach J]]