View source for 2m64


==1H, 13C and 15N Chemical Shift Assignments for Phl p 5a==
<StructureSection load='2m64' size='340' side='right'caption='[[2m64]]' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[2m64]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Phleum_pratense Phleum pratense]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2M64 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2M64 FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2m64 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2m64 OCA], [https://pdbe.org/2m64 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2m64 RCSB], [https://www.ebi.ac.uk/pdbsum/2m64 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2m64 ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/MPAP5_PHLPR MPAP5_PHLPR] 
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
This is the first study determining the three-dimensional structure of Phl p 5a which reveals a novel mechanism for high allergenic activity based on flexibly connected IgE-reactive domains which cross-link effector cell-bound IgE more efficiently than isolated rigid globular proteins. These findings may also form a basis for specific immunotherapy strategies.

Flexible IgE epitope-containing domains of Phl p 5 cause high allergenic activity.,Gobl C, Focke-Tejkl M, Najafi N, Schrank E, Madl T, Kosol S, Madritsch C, Dorofeeva Y, Flicker S, Thalhamer J, Valenta R, Zangger K, Tjandra N J Allergy Clin Immunol. 2017 Oct;140(4):1187-1191. doi: , 10.1016/j.jaci.2017.05.005. Epub 2017 May 19. PMID:28532654<ref>PMID:28532654</ref>

From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
<div class="pdbe-citations 2m64" style="background-color:#fffaf0;"></div>
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Phleum pratense]]
[[Category: Flicker S]]
[[Category: Focke M]]
[[Category: Goebl C]]
[[Category: Kosol S]]
[[Category: Madl T]]
[[Category: Madritsch C]]
[[Category: Schrank E]]
[[Category: Tjandra N]]
[[Category: Valenta R]]
[[Category: Zangger K]]