View source for 2m3d


==NMR structure of the GUCT domain from human DEAD box polypeptide 21==
<StructureSection load='2m3d' size='340' side='right'caption='[[2m3d]]' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[2m3d]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2M3D OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2M3D FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2m3d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2m3d OCA], [https://pdbe.org/2m3d PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2m3d RCSB], [https://www.ebi.ac.uk/pdbsum/2m3d PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2m3d ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/DDX21_HUMAN DDX21_HUMAN] RNA helicase that acts as a sensor of the transcriptional status of both RNA polymerase (Pol) I and II: promotes ribosomal RNA (rRNA) processing and transcription from polymerase II (Pol II) (PubMed:25470060). Binds various RNAs, such as rRNAs, snoRNAs, 7SK and, at lower extent, mRNAs (PubMed:25470060). In the nucleolus, localizes to rDNA locus, where it directly binds rRNAs and snoRNAs, and promotes rRNA transcription, processing and modification. Required for rRNA 2'-O-methylation, possibly by promoting the recruitment of late-acting snoRNAs SNORD56 and SNORD58 with pre-ribosomal complexes (PubMed:25470060, PubMed:25477391). In the nucleoplasm, binds 7SK RNA and is recruited to the promoters of Pol II-transcribed genes: acts by facilitating the release of P-TEFb from inhibitory 7SK snRNP in a manner that is dependent on its helicase activity, thereby promoting transcription of its target genes (PubMed:25470060). Functions as cofactor for JUN-activated transcription: required for phosphorylation of JUN at 'Ser-77' (PubMed:11823437, PubMed:25260534). Can unwind double-stranded RNA (helicase) and can fold or introduce a secondary structure to a single-stranded RNA (foldase) (PubMed:9461305). Involved in rRNA processing (PubMed:14559904, PubMed:18180292).<ref>PMID:11823437</ref> <ref>PMID:14559904</ref> <ref>PMID:18180292</ref> <ref>PMID:25260534</ref> <ref>PMID:25470060</ref> <ref>PMID:25477391</ref> <ref>PMID:9461305</ref> 

==See Also==
*[[Helicase 3D structures|Helicase 3D structures]]
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Dutta SK]]
[[Category: Geralt M]]
[[Category: Serrano P]]
[[Category: Wuthrich K]]