View source for 2lrs


==The second dsRBD domain from A. thaliana DICER-LIKE 1==
<StructureSection load='2lrs' size='340' side='right'caption='[[2lrs]]' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[2lrs]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Arabidopsis_thaliana Arabidopsis thaliana]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LRS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2LRS FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2lrs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2lrs OCA], [https://pdbe.org/2lrs PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2lrs RCSB], [https://www.ebi.ac.uk/pdbsum/2lrs PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2lrs ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/DCL1_ARATH DCL1_ARATH] Ribonuclease (RNase) III involved in RNA-mediated post-transcriptional gene silencing (PTGS). Functions in the microRNAs (miRNAs) biogenesis pathway by cleaving primary miRNAs (pri-miRNAs) and precursor miRNAs (pre-miRNAs). Functions with DRB1/HYL1 and SERRATE proteins for accurate pri-miRNAs to miRNAs processing. Indirectly involved in the production of trans-acting small interfering RNAs (ta-siRNAs) derived from the TAS1, TAS2 or TAS3 endogenous transcripts by participating in the production of their initiating miRNAs. Involved in the processing of natural siRNAs (nat-siRNAs, derived from cis-natural antisense transcripts) by cleaving 24 nucleotide nat-siRNAs into 21 nucleotide nat-siRNAs. Can produce RDR6-dependent endogenous ta-siRNAs derived from TAS1 and TAS2. Required for the production of 30-40 nucleotide bacterial-induced long siRNAs (lsiRNA). Acts redundantly with DICER-LIKE 3 (DCL3) to promote flowering via repression of FLOWERING LOCUS C (FLC). Represses antiviral RNA silencing through negative regulation of the expression of DCL4 and DCL3.<ref>PMID:15821876</ref> <ref>PMID:16040244</ref> <ref>PMID:16428603</ref> <ref>PMID:17579240</ref> <ref>PMID:18003861</ref> <ref>PMID:18632569</ref> <ref>PMID:18799732</ref> 
== References ==
<references/>
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</StructureSection>
[[Category: Arabidopsis thaliana]]
[[Category: Large Structures]]
[[Category: Bersch B]]
[[Category: Boisbouvier J]]
[[Category: Bologna N]]
[[Category: Burdisso P]]
[[Category: Palatnik J]]
[[Category: Rasia R]]
[[Category: Suarez I]]