View source for 2l2m


==Solution structure of the second dsRBD of HYL1==
<StructureSection load='2l2m' size='340' side='right'caption='[[2l2m]]' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[2l2m]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Arabidopsis_thaliana Arabidopsis thaliana]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2L2M OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2L2M FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2l2m FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2l2m OCA], [https://pdbe.org/2l2m PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2l2m RCSB], [https://www.ebi.ac.uk/pdbsum/2l2m PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2l2m ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/DRB1_ARATH DRB1_ARATH] Double-stranded RNA-binding protein involved in RNA-mediated post-transcriptional gene silencing (PTGS). Functions in the microRNAs (miRNAs) biogenesis by assisting DICER-LIKE 1 (DCL1) in the accurate processing from primary miRNAs (pri-miRNAs) to miRNAs in the nucleus. Forms a complex with SERRATE (SE) and DCL1 to promote accurate processing of pri-miRNAs by DCL1. Binds and assist DCL1 for accurate processing of precursor miRNAs (pre-miRNA). Indirectly involved in the production of trans-acting small interfering RNAs (ta-siRNAs) derived from the TAS1, TAS2 or TAS3 endogenous transcripts by participating in the production of their initiating miRNAs. Involved with argonaute 1 (AGO1) in the guide strand selection from miRNA duplexes, presumably by directional loading of the miRNA duplex (guide stand and passenger strand) onto the RNA-induced silencing complex (RISC) for passenger strand degradation. Does not participate in sense transgene-induced post-transcriptional gene silencing (S-PTGS). Involved in several plant development aspects and response to hormones through its role in miRNAs processing.<ref>PMID:11148283</ref> <ref>PMID:14722360</ref> <ref>PMID:14972688</ref> <ref>PMID:15821876</ref> <ref>PMID:16428603</ref> <ref>PMID:16889646</ref> <ref>PMID:17337628</ref> <ref>PMID:18632569</ref> <ref>PMID:19304749</ref> <ref>PMID:19861421</ref> <ref>PMID:20462493</ref> <ref>PMID:20735118</ref> 
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/l2/2l2m_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2l2m ConSurf].
<div style="clear:both"></div>
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Arabidopsis thaliana]]
[[Category: Large Structures]]
[[Category: Boisbouvier J]]
[[Category: Bologna NG]]
[[Category: Burdisso P]]
[[Category: Imbert L]]
[[Category: Mateos JL]]
[[Category: Palatnik JF]]
[[Category: Rasia RM]]