View source for 2l14


==Structure of CBP nuclear coactivator binding domain in complex with p53 TAD==
<StructureSection load='2l14' size='340' side='right'caption='[[2l14]]' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[2l14]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2L14 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2L14 FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2l14 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2l14 OCA], [https://pdbe.org/2l14 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2l14 RCSB], [https://www.ebi.ac.uk/pdbsum/2l14 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2l14 ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/CBP_MOUSE CBP_MOUSE] Acetylates histones, giving a specific tag for transcriptional activation. Also acetylates non-histone proteins, like NCOA3 and FOXO1. Binds specifically to phosphorylated CREB and enhances its transcriptional activity toward cAMP-responsive genes. Acts as a coactivator of ALX1 in the presence of EP300 (By similarity).<ref>PMID:10207073</ref> <ref>PMID:11701890</ref> <ref>PMID:15220471</ref> <ref>PMID:16287980</ref> 

==See Also==
*[[CREB-binding protein 3D structures|CREB-binding protein 3D structures]]
*[[P53 3D structures|P53 3D structures]]
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Mus musculus]]
[[Category: Dyson HJ]]
[[Category: Lee C]]
[[Category: Martinez-Yamout MA]]
[[Category: Wright PE]]