View source for 2krk


==Solution NMR Structure of 26S protease regulatory subunit 8 from H.sapiens, Northeast Structural Genomics Consortium Target Target HR3102A==
<StructureSection load='2krk' size='340' side='right'caption='[[2krk]]' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[2krk]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KRK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2KRK FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2krk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2krk OCA], [https://pdbe.org/2krk PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2krk RCSB], [https://www.ebi.ac.uk/pdbsum/2krk PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2krk ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/PRS8_HUMAN PRS8_HUMAN] The 26S protease is involved in the ATP-dependent degradation of ubiquitinated proteins. The regulatory (or ATPase) complex confers ATP dependency and substrate specificity to the 26S complex.
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/kr/2krk_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2krk ConSurf].
<div style="clear:both"></div>

==See Also==
*[[Proteasome 3D structures|Proteasome 3D structures]]
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Acton TB]]
[[Category: Ciccosanti C]]
[[Category: Everett JK]]
[[Category: Janjua J]]
[[Category: Liu G]]
[[Category: Montelione GT]]
[[Category: Nair R]]
[[Category: Rost B]]
[[Category: Shastry R]]
[[Category: Xiao R]]