View source for 2cpr


==Solution structure of the HRDC domain of human Exosome component 10==
<StructureSection load='2cpr' size='340' side='right'caption='[[2cpr]]' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[2cpr]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CPR OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2CPR FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2cpr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2cpr OCA], [https://pdbe.org/2cpr PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2cpr RCSB], [https://www.ebi.ac.uk/pdbsum/2cpr PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2cpr ProSAT], [https://www.topsan.org/Proteins/RSGI/2cpr TOPSAN]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/EXOSX_HUMAN EXOSX_HUMAN] Putative catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding 'pervasive' transcripts, such as antisense RNA species and promoter-upstream transcripts (PROMPTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cytoplasm. The RNA exosome may be involved in Ig class switch recombination (CSR) and/or Ig variable region somatic hypermutation (SHM) by targeting AICDA deamination activity to transcribed dsDNA substrates. In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and specifically degrades inherently unstable mRNAs containing AU-rich elements (AREs) within their 3' untranslated regions, and in RNA surveillance pathways, preventing translation of aberrant mRNAs. It seems to be involved in degradation of histone mRNA. EXOSC10 has 3'-5' exonuclease activity (By similarity). EXOSC10 is required for nucleolar localization of C1D and probably mediates the association of SKIV2L2, C1D and MPP6 wth the RNA exosome involved in the maturation of 5.8S rRNA.<ref>PMID:14527413</ref> <ref>PMID:16455498</ref> <ref>PMID:17412707</ref> <ref>PMID:17545563</ref> <ref>PMID:18172165</ref> <ref>PMID:19056938</ref> <ref>PMID:20699273</ref> <ref>PMID:20368444</ref> 
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/cp/2cpr_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2cpr ConSurf].
<div style="clear:both"></div>

==See Also==
*[[Exosome 3D structures|Exosome 3D structures]]
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Inoue M]]
[[Category: Kigawa T]]
[[Category: Muto Y]]
[[Category: Nagata T]]
[[Category: Shirouzu M]]
[[Category: Terada T]]
[[Category: Yokoyama S]]